Effects of Facial Platelet-Rich Plasma Treatment in Patients Without Prior Aesthetic Procedures in Asunción, Paraguay

Authors

  • Carolina Villalba Alvarenga 1 Universidad Nacional de Caaguazu, Facultad de Ciencias Médicas, Especialización en Medicina Estética y Envejecimiento Fisiológico, Coronel Oviedo, Paraguay. https://orcid.org/0009-0007-5328-3939

Keywords:

Platelet-rich plasma, photoaging, aesthetic medicine, biostimulation, facial rejuvenation

Abstract

Introduction: Platelet-rich plasma (PRP) has proven to be a safe and minimally invasive therapeutic option in aesthetic medicine, with bio-stimulatory effects on facial skin. However, few studies have assessed its efficacy in patients without prior aesthetic treatments.

Objective: To evaluate the clinical effects of facial PRP treatment in patients without previous aesthetic procedures, treated in a clinic in Asunción during 2022 and 2023.

Materials and Methods: Observational, descriptive. A total of 30 female patients over 18 years of age, with no prior aesthetic procedures, were included. Demographic data, skin phototype, photoaging grade, clinical results (skin smoothness, wrinkles, acne scars, and hyperpigmentation), and adverse events were evaluated.

Results: Most patients were between 30 and 35 years old (73.3%), had Fitzpatrick phototype II (70%), and Glogau grade II photoaging (53.4%). Improvement in skin smoothness was observed in 100% of cases, reduction of wrinkles in 60%, attenuation of acne scars in 30%, and hyperpigmentation in 15%. Adverse events included hematomas in 16.7%, hypersensitivity in 13.3%, inflammation in 10%, and edema in 3.3%.

Conclusion: Facial PRP was found to be effective and safe in patients without previous aesthetic interventions, showing improvement in skin quality with minimal adverse effects. Early use is recommended as an initial biostimulatory option in facial aesthetics.

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References

1. Velarde MC, Flynn JM, Day NU, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012;4(1):3‐12. https://doi.org/10.18632/aging.100423

2. Eppley BL, Pietrzak WS, Blanton M. Platelet‐rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006;118(6):147e‐147e. https://doi.org/10.1097/01.prs.0000239606.92676.cf

3. Piipponen M, Li D, Landén NX. The immune functions of keratinocytes in skin wound healing. Int J Mol Sci. 2020; 21(22):8790. https://doi.org/10.3390/ijms21228790

4. Andia I, Abate M. Platelet‐rich plasma: underlying biology and clinical correlates. Regen Med. 2013;8(5):645‐658. https://doi.org/10.2217/rme.13.59

5. Alves R, Grimalt R. A review of platelet‐rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord. 2018;4(1):18‐24. https://doi.org/10.1159/000477353

6. Conde Montero E, Fernández Santos ME, Suárez Fernández R. Platelet‐rich plasma: applications in dermatology. Actas Dermosifiliogr. 2015;106(2):104‐111. https://doi.org/10.1016/j.ad.2013.12.021

7. Magruder ML, Caughey S, Gordon AM, Capotosto BSS, Rodeo SA. Trends in utilization, demographics, and costs of platelet‐rich plasma injections: a ten‐year nationwide investigation. Phys Sportsmed. 2024;52(1):89‐97. https://doi.org/10.1080/00913847.2023.2178816

8. Andia I, Rubio‐Azpeitia E, Martin JI, Abate M. Current concepts and translational uses of platelet rich plasma biotechnology. In: Deniz E, ed. Biotechnology. IntechOpen; 2015:Ch. 1. https://scholar.google.com/scholar_lookup?title=Biotechnology&author=I%20Andia&author=E%20Rubio%E2%80%90Azpeitia&author=JI%20Martin&author=M%20Abate&publication_year=2015&

9. Wu CC, Wu YN, HO Ho, Chen KC, Sheu MT, Chiang HS. The neuroprotective effect of platelet‐rich plasma on erectile function in bilateral cavernous nerve injury rat model. J Sex Med. 2012;9(11):2838‐2848. https://doi.org/10.1111/j.1743-6109.2012.02881.x

10. Wu YN, Wu CC, Sheu MT, Chen KC, HO Ho, Chiang HS. Optimization of platelet‐rich plasma and its effects on the recovery of erectile function after bilateral cavernous nerve injury in a rat model. J Tissue Eng Regen Med. 2016;10(10):E294‐E304. https://doi.org/10.1002/term.1806

11. Dankova I, Pyrgidis N, Tishukov M, et al. Efficacy and safety of platelet‐rich plasma injections for the treatment of female sexual dysfunction and stress urinary incontinence: a systematic review. Biomedicines. 2023;11(11):2919. https://doi.org/10.3390/biomedicines11112919

12. Matz EL, Scarberry K, Terlecki R. Platelet‐rich plasma and cellular therapies for sexual medicine and beyond. Sex Med Rev. 2022;10(1):174‐179. https://doi.org/10.1016/j.sxmr.2020.07.001

13. Wang Z, Feng C, Chang G, Liu H, Li S. The use of platelet‐rich plasma in wound healing and vitiligo: a systematic review and meta‐analysis. Skin Res Technol. 2023;29(9):e13444. https://doi.org/10.1111/srt.13444

14. Wei W, Zhang Y, Long B, Zhang Y, Zhang C, Zhang S. Injections of platelet‐rich plasma prepared by automatic blood cell separator combined with topical 5% minoxidil in the treatment of male androgenetic alopecia. Skin Res Technol. 2023;29(7):e13315. https://doi.org/10.1111/srt.13315

15. Li ZJ, Choi H‐I, Choi D‐K, et al. Autologous platelet‐rich plasma: a potential therapeutic tool for promoting hair growth. Dermatol Surg. 2012;38(7pt1):1040‐1046. https://doi.org/10.1111/j.1524-4725.2012.02394.x

Published

2025-08-08

How to Cite

1.
Villalba Alvarenga C. Effects of Facial Platelet-Rich Plasma Treatment in Patients Without Prior Aesthetic Procedures in Asunción, Paraguay. Cienc. Est. [Internet]. 2025 Aug. 8 [cited 2026 May 25];1(2):58-63. Available from: https://www.cienciayestetica.org/index.php/revista/article/view/12

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